Khan A, Safdar M, Khan MMA et al (2003) Cinnamon improves glucose and lipids of people with Type 2 diabetes. Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Song Y, He K, Levitan B et al (2006) Effects of oral magnesium supplementation on glycaemic control in Type 2 diabetes: a meta-analysis of randomized double-blind controlled trials. Ann Fam Med 11:452–459īalk EM, Tatsioni A, Lichtenstein A et al (2007) Effect of chromium supplementation on glucose metabolism and lipids: a systematic review of randomized controlled trials. Clin Nutr 31:609–615Īllen R, Schwartzman E, Baker W et al (2013) Cinnamon use in Type 2 diabetes: an updated systematic review and meta-analysis. Molecules 17:248–266Īkilen R, Tsiami A, Devendra D, Robinson N (2012) Cinnamon in glycaemic control: systematic review and meta-analysis. Diabet Med 2:371–373Įrejuwa OO, Sulaiman SA, Ab Wahab MS (2012) Oligosaccharides might contribute to the antidiabetic effect of honey: a review of the literature. Samanta A, Burden AC, Jones AR (1985) Plasma glucose responses to glucose, sucrose and honey in patients with diabetes mellitus: an analysis of glycaemic and peak incremental indices. Int J Biol Sci 8:913–934Įrejuwa OO, Sulaiman SA, Ab Wahab MS et al (2001) Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats. J Med Food 7:100–107Įrejuwa OO, Sulaiman SA, Ab Wahab MS (2012) Honey: a novel antidiabetic agent.

J Med Food 10:473–478Īl-Waili NS (2004) Natural honey lowers plasma glucose, C-reactive protein, homocysteine and blood lipids in healthy, diabetic and hyperlipidemic subjects: Comparison with dextrose and sucrose. Accessed Īgrawal OP, Pachauri A, Yadav H et al (2007) Subjects with impaired glucose tolerance exhibit a high degree of tolerance to honey. Use of the formulated honey was associated with a reduction in weight and improvements in lipid parameters, and should be investigated further. The addition of cinnamon, chromium and magnesium supplementation to kanuka honey was not associated with a significant improvement in glucose metabolism or glycaemic control in individuals with type 2 diabetes. There was a trend towards increased HDL and reduced systolic blood pressure in the intervention treatment. There was no statistically significant change in HbA1c or fasting insulin. After the 40-day intervention with honey, fasting glucose did not differ significantly between the two treatments (95 % CI −2.6 to 0.07). There was no statistically significant difference in acute glucose metabolism between treatment groups, as measured by the Matsuda index and AUC for glucose and insulin.

A meal tolerance test was performed at baseline to assess acute metabolic response. Fasting glucose, insulin, HbA1c, lipids and anthropometric measures were measured at baseline and end of treatment. Twelve individuals with type 2 diabetes received 53.5 g of a formulated honey and a control (non-formulated) kanuka honey in a random order for 40 days, using cross-over design.

This randomised controlled trial assessed the acute and long-term effects of daily supplementation of kanuka honey, formulated with cinnamon, chromium and magnesium on glucose metabolism, weight and lipid parameters in individuals with type 2 diabetes.

Magnesium and chromium for diabetes